Congenic rats with higher arylamine N-acetyltransferase 2 activity exhibit greater carcinogen-induced mammary tumor susceptibility independent of carcinogen metabolism

Atm-haploinsufficiency enhances susceptibility to carcinogen-induced mammary tumors.

Ataxia-telangiectasia (A-T), which is due to mutations in the ATM gene, is a rare autosomal recessive genomic instability syndrome characterized by radiosensitivity and predisposition to cancer. Epidemiological studies have suggested that relatives of A-T patients (A-T carriers) have increased risks of developing breast cancer. We propose that increased breast cancer risks in A-T carriers may b...

NAT 2 ( N - acetyltransferase 2 ( arylamine N - acetyltransferase ) )

The Metabolism of the Pancreas Carcinogen N-nitrosobis(2-oxopr

Context We have isolated five stable clones from a primary culture of Syrian golden hamster pancreatic duct epithelial cells and have designated them as CK1 through CK5. Design Here we describe the ability of two of these, CK1 and CK5, to metabolize the pancreas carcinogen N-nitrosobis(2oxopropyl)amine. The metabolism was assessed as the production of mutated V79 cells in a CK cell/V79 co-cultu...

Importance of mammary gland DNA synthesis on carcinogen-induced mammary tumorigenesis in rats.

DNA synthesis in mammary gland estimated by [3H]thymidine incorporation was significantly higher on the day of proestrus than on the second day of diestrus in 50-day-old female Sprague-Dawley rats. The percentage of progressive mammary tumors, tumor growth rate, and the number and the weight of tumors per tumor-bearing rat were significantly higher in the animals given a single i.v. injection o...

Arylamine N-acetyltransferase.

304 3.5. Namboodiri. kl. A. A,. Nakai. C‘. k Klein, 1). C. (1070) J. Ncurochem. 33. 807-810 30. Klein. 1). C’. k Namboodiri, M. A. A. (1082) Trends Biochem. Sci. 7, OXI02 37. Namboodiri, M. A. A,, Weller, J. I , . Kc Klein, I). C’. (1080) J. l k l . Cheni. 255. 6032-0035 38. Namboodiri, M. A. A,. Weller, J. I, . K: Klein, I). C’. ( 1080) Hiochem. Hiophys. Kes. C’ommun. 96, 1 8%1 05 30 . Niimboo...